VUW researchers have designed an synthesized a family of novel analogues based on furo[3,4-ß]pyran, a fungal secondary metabolite shown to have src-kinase inhibition activity.
The family of derivative compounds exhibit improved kinase inhibition, showing desirable selectivity between the kinase classes.
The furo[3,4-ß]pyran scaffold lends itself to multiple sites for chemical modification, structure-activity studies and the creation of new composition of matter intellectual property. Our current family of compounds based on the scaffold have very strong inhibition against BMX and BTK, which have been implicated in a range of auto-immune and oncology therapy applications.
A Senior Lecturer in chemistry at Victoria University of Wellington’s School of Chemical and Physical Sciences, Dr Joanne Harvey’s research focuses on organic synthesis. Her research contributes to the activities of the Centre for Biodiscovery. Chemical synthesis and the extraction of natural products from plants, algae and bacteria are complementary methods for discovering novel and bioactive mo...